At our clinic, skin booster layering treatments are performed in the following steps.

1. Pre-treatment preparation and skin cleansing

• Cooling or anesthetic cream may be applied depending on the patient's condition.

This is the 4-D layering skin booster treatment process proposed by our clinic.

2. 4-step skin booster layering application (using MTS or Potenza RF)

• Step 1: The skin booster ampoule is applied for the first time.

It is thinly applied to the epidermal layer of the skin to provide an overall priming effect and induce skin response.

• Step 2: The second skin booster ampoule is applied.

After light needling targeting the superficial layers of the epidermis and dermis, it is applied.

• Step 3: The third skin booster ampoule is applied.

To primarily manage the 'deep dermal layer,' which acts as a support for the skin, the needle depth is adjusted, and then it is applied after the procedure.

• Step 4: Finally, the skin booster ampoule is applied.

After intensive needling on the areas the patient wishes to improve, such as enlarged pores, reduced elasticity, or firm scar borders, the ampoule is applied.

3. Post-treatment skin soothing care

• The treatment concludes by comfortably soothing the skin using a Jaungo modeling pack.

At our clinic, we apply a 4-step layering technique in a single treatment. This helps skin booster ingredients spread evenly throughout the dermal layer and be absorbed deeply. The skin booster layering treatment provided at our clinic is performed in a way that focuses on reducing discomforts such as bruising, swelling, medication injection errors, and hypersensitivity reactions.

Layering Method for Delivering Skin Boosters to the Skin at Our Clinic

Due to the particle characteristics of Olidia myo, there are limitations to ingredient absorption when simply applied to the skin surface. Therefore, our clinic utilizes MTS (Microneedle Therapy System) and needle radiofrequency (Potenza RF) devices to absorb skin boosters through a layering technique.

Olidia myo consists of particles with an average size of approximately 32㎲. This ingredient can be well absorbed into the skin through the microscopic channels created by MTS and Potenza RF devices. Compared to simple topical application, the procedure is performed using a delicate layering technique to reduce drug loss and deliver the ingredients to the deep dermal layer of the skin.

1) Layering Treatment Method Using MTS

MTS devices create microscopic channels for drug absorption in the skin. At our clinic, we meticulously adjust the depth of MTS needles in 4 steps and apply a layering method to help enhance ingredient absorption.

• Priming application is performed on the epidermal layer of the skin.

• After shallow needling, it is applied targeting the epidermis and upper dermis.

• It is applied to focus on managing the deep dermal layer.

• It is applied specifically to target areas requiring improvement, such as reduced elasticity, deep scars, or enlarged pores.

Following this, soothing care, such as a Jaungo modeling pack, is performed to help reduce the burden of inflammatory reactions and ensure a comfortable finish to the treatment.

2) Layering Treatment Method Using Potenza RF Microneedle Radiofrequency

Potenza RF uses fine microneedles to create uniform absorption channels in the skin. Subsequently, radiofrequency thermal energy is emitted, which can help prevent fluid reflux, a common occurrence in typical needle procedures, as the surrounding tissue coagulates and contracts. This reduces drug loss and helps ensure that the Olidia myo ingredients are evenly delivered throughout the entire dermal layer.

This procedure can contribute to more even drug delivery. Particularly, when radiofrequency (RF) thermal energy and Olidia myo (PLLA) ingredients work together, positive effects on promoting collagen production both inside and on the surface of the skin can be expected. Similar to MTS, needle depth can be adjusted, and the treatment is performed using a 4-step layering technique that reaches the deep dermal layer.

At our clinic, we appropriately combine and apply MTS and Potenza RF treatments, taking into account the patient's skin condition, degree of aging, and scar depth.

We explain why our clinic chose this treatment method.

Olidia myo is provided in the form of a high-concentration, high-molecular PLLA powder. For this ingredient, the process of sufficiently hydrating it with saline in an appropriate ratio to create a stable viscosity is important.

If the drug is injected intensely into one area using a typical injection method or if depth control is insufficient, there is a possibility that the drug may clump together, forming nodules. Even if the hydration process is consistently carried out, there may still be concerns about nodule side effects in conventional injection procedures.

Therefore, our clinic is carefully approaching this by considering methods that aim to reduce the possibility of side effects such as nodules, while still expecting the treatment's effectiveness.

At our clinic, we meticulously manage everything from the drug hydration process, unique viscosity control, creation of microscopic channels, to the 4-step layering technique. This helps ensure that the ingredient particles act evenly within the tissue without clumping, leading to gradual improvements. Our treatment principle is to enhance treatment effectiveness while minimizing potential risks.

Introducing Olidia myo Skin Booster.

Olidia myo is an autologous collagen booster primarily composed of pure PLLA (Poly-L-lactic acid), with mannitol and CMC also included. This ingredient primarily acts on the 'deep dermal layer,' which is deeper than typical skin boosters. Beyond simply improving the skin's surface, it can help fundamentally improve the extracellular matrix (ECM) structure, which acts as a supportive pillar for the skin.

Main Ingredients of Olidia myo (Total 121.7mg)

• Pure PLLA 50mg: A substance that helps stimulate the skin's autologous collagen and extracellular matrix (ECM) production.

• Mannitol 41.7mg: An ingredient that protects the freeze-dried state and can also contribute to antioxidant activity.

The CMC 30mg ingredient acts as a natural thickener, which can help maintain the stable viscosity of the injected solution during treatment.

Reasons for using amorphous PLLA instead of spherical particles

Existing spherical particles, with their round and smooth shape, can be difficult for macrophages to absorb, potentially leading to a slower reaction rate in the body. In contrast, Olidia Mayo utilizes well-faceted, stone-shaped amorphous particles, which induce macrophages to attach more quickly due to their larger surface area.

The particle size is precisely designed to reduce situations where cells might be damaged by over-absorbing particles. Instead, it induces the activation of M2 macrophages, which promotes the secretion of TH2 cytokines during this process. These signaling substances effectively stimulate fibroblasts in the skin, contributing to the generation of natural collagen and autologous tissue.

While existing PDLLA-based products (such as Juvelook) primarily worked on the superficial layers of the skin to provide gentle stimulation, Olidia Mayo can help induce collagen production by remaining in the deeper dermis for a longer period.

Consider this treatment if you are experiencing:

1. Individuals concerned about a sudden decrease in skin elasticity and reduced elasticity in the deep dermal layer.

2. Individuals who have not seen sufficient improvement in pores or deep acne scars with typical skin booster treatments.

3. Individuals who desire natural improvement in skin density through autologous tissue generation, rather than artificial-looking fillers.

4. Individuals concerned about reduced elasticity and fine wrinkles due to weakened supporting structures (ECM) within the skin.

5. Individuals interested in the effects of PLLA but concerned about potential nodules or pain during injection procedures.

6. Individuals expecting tightening and lifting effects with elastic replenishment from deep within the skin.

What is the clinical evidence for Olidia Mayo's ingredients?

Several studies and academic papers on Olidia Mayo's ingredients support its characteristics.

• Physical approaches to biomaterial design, Nature Materials: Research shows that particle shape and geometric structure influence macrophage response. It explains that amorphous structures with a large surface area can help reduce cell stimulation while efficiently degrading in the body.

• PLLA Clinical Long-term Follow-up Study: Authentic PLLA ingredients are reported to remain in body tissues for a relatively long period, from 9 months up to 24 months. Furthermore, it suggests that through gradual and consistent reactions, it can contribute to more sustained collagen production compared to PDLLA (DL-form).